TSR3

Entrez Summary: N/A
UniProt Summary: Probable pre-rRNA processing protein involved in ribosome biogenesis. {ECO:0000255|HAMAP-Rule:MF_03146}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Quercetin 20μM R08 exp517	-2.32
TRAIL 50ng/ml R00 exp36	-2.2
LB-100 2μM R05 exp210	-2.13
NFN1 1μM R03 exp100	-2.07
UM0129480 7μM R02 exp85	-2
TRAIL 5ng/ml R00 exp35	-1.99
Parthenolide 2.5μM R05 exp238	-1.96
Ibrutinib 10μM R08 exp442	-1.91
Colchicine 0.009μM R05 exp215	-1.9
Mdivi-1 15μM R05 exp217	-1.85
VER-155008 3.9μM R06 exp301	-1.77
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-1.76
Alpha-Amanitin 0.5μM R00 exp5	-1.76
Bortezomib 0.005μM R00 exp6	-1.73
Ibrutinib 1μM R07 exp372	-1.71
Rapamycin 1μM R00 exp29	1.75
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.75
Tunicamycin 0.04μM R07 exp418	1.77

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

RLI
DUF367

rRNA modification
maturation of SSU-rRNA
transferase activity
ribosomal small subunit biogenesis
RNA modification
rRNA processing
rRNA metabolic process
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
RNA processing
RNA metabolic process
gene expression