TTC26

Entrez Summary: N/A
UniProt Summary: Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI3 at the ciliary tip and its dissociation from SUFU. {ECO:0000250|UniProtKB:Q8BS45}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

manchette assembly
intraciliary anterograde transport
intraciliary transport particle B binding
intraciliary transport particle B
ciliary base
intraciliary transport involved in cilium assembly
ciliary tip
protein localization to cilium
intraciliary transport
axoneme assembly
microtubule-based protein transport
protein transport along microtubule
smoothened signaling pathway
microtubule bundle formation
motile cilium
ciliary basal body
spermatid development
transport along microtubule
spermatid differentiation
cytoskeleton-dependent intracellular transport
microtubule-based transport
cilium
germ cell development
protein-containing complex localization
microtubule-based movement
cilium assembly
cellular process involved in reproduction in multicellular organism
cilium organization
plasma membrane bounded cell projection assembly
cell projection assembly
microtubule cytoskeleton organization
centrosome
spermatogenesis
male gamete generation
developmental process involved in reproduction
microtubule-based process
gamete generation
protein localization to organelle
organelle assembly
multicellular organismal reproductive process