USPL1

Entrez Summary: N/A
UniProt Summary: SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (PubMed:22878415). Plays a key role in RNA polymerase-II- mediated snRNA transcription in the Cajal bodies (PubMed:24413172). Is a component of complexes that can bind to U snRNA genes (PubMed:24413172). {ECO:0000269|PubMed:22878415, ECO:0000269|PubMed:24413172}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 408/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	20/28
blood	13/28
bone	9/26
breast	13/33
central nervous system	36/56
cervix	4/4
colorectal	7/17
esophagus	7/13
fibroblast	1/1
gastric	10/16
kidney	10/21
liver	13/20
lung	45/75
lymphocyte	5/16
ovary	16/26
pancreas	13/24
peripheral nervous system	9/16
plasma cell	10/15
prostate	0/1
skin	13/24
soft tissue	5/9
thyroid	1/2
upper aerodigestive	12/22
urinary tract	16/29
uterus	5/5

Expression Distribution

Screen	Score
L-74142 5μM R03 exp131	1.7
Nifuroxazide 1μM R01 exp51	1.75

SUMO-specific isopeptidase activity
Cajal body organization
protein desumoylation
SUMO binding
nuclear body organization
Cajal body
snRNA transcription
ubiquitin binding
ncRNA transcription
nucleus organization
protein modification by small protein removal
peptidyl-lysine modification
cell population proliferation
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
peptidyl-amino acid modification
protein modification by small protein conjugation or removal
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
proteolysis
organic cyclic compound biosynthetic process
extracellular space
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression