WDR33

Entrez Summary: N/A
UniProt Summary: Essential for both cleavage and polyadenylation of pre- mRNA 3' ends. {ECO:0000269|PubMed:19217410}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hydroxyurea 100μM R07 exp329	-2.35
Tubastatin-A 2.5μM R07 exp417	-2.15
TIC10 10μM R08 exp532	-1.86
Torin1 0.08μM R02 exp82	-1.85
Monensin 0.3μM R08 exp507	-1.82
NMS-873 0.07μM R07 exp380	-1.71
Senexin-A 25μM R07 exp400	-1.71
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	1.8
MS023 2μM R03 exp134	2.35

Global Fraction of Cell Lines Where Essential: 12/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	2/28
bone	0/26
breast	0/33
central nervous system	2/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

WD40
Collagen

mRNA cleavage and polyadenylation specificity factor complex
mRNA polyadenylation
RNA polyadenylation
termination of RNA polymerase II transcription
postreplication repair
collagen trimer
DNA-templated transcription, termination
mRNA 3-end processing
mRNA-containing ribonucleoprotein complex export from nucleus
mRNA export from nucleus
ribonucleoprotein complex export from nucleus
ribonucleoprotein complex localization
RNA export from nucleus
fibrillar center
RNA 3-end processing
protein export from nucleus
mRNA transport
nuclear export
RNA transport
nucleic acid transport
establishment of RNA localization
RNA localization
nucleobase-containing compound transport
protein-containing complex localization
nucleocytoplasmic transport
nuclear transport
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
RNA splicing
mRNA processing
transcription by RNA polymerase II
DNA repair
spermatogenesis
male gamete generation
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
gamete generation
mRNA metabolic process