WRB

Entrez Summary: N/A
UniProt Summary: Receptor for ASNA1/TRC40-mediated insertion of tail- anchored (TA) proteins into the ER membrane. {ECO:0000269|PubMed:21444755}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cerivastatin 0.15μM R05 exp226	-2.6
Beta-Estradiol 0.55μM R07 exp425	-2.28
GSK591 2.6μM R03 exp128	-1.9
MLN-4924 0.2μM R00 exp21	-1.89
NN-Dimethylsphingosine 2.5μM R08 exp508	-1.88
Demecolcine 0.03μM R05 exp228	-1.84
Taxol 0.004μM R03 exp103	-1.8
A-769662 20μM R07 exp331	-1.76
ABT-702 0.1μM R06 exp260	-1.74
HMS-I2 1μM R06 exp286	-1.72
Thimerosal 0.85μM R08 exp529	1.81
∆-9-Tetrahydrocannabinol 30μM R08 exp445	2.15

Global Fraction of Cell Lines Where Essential: 104/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	7/28
blood	2/28
bone	3/26
breast	5/33
central nervous system	10/56
cervix	0/4
colorectal	7/17
esophagus	4/13
fibroblast	0/1
gastric	2/16
kidney	8/21
liver	5/20
lung	13/75
lymphocyte	2/16
ovary	1/26
pancreas	3/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	4/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	4/22
urinary tract	7/29
uterus	1/5

Expression Distribution

tail-anchored membrane protein insertion into ER membrane
protein insertion into ER membrane
protein insertion into membrane
endoplasmic reticulum organization
establishment of protein localization to membrane
endomembrane system organization
protein localization to membrane
protein localization to organelle
membrane organization
endoplasmic reticulum membrane
endoplasmic reticulum
cellular protein localization
cellular macromolecule localization
establishment of protein localization