YBX1

Entrez Summary: N/A
UniProt Summary: Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5'-[CU]CUGCG-3' motif in vitro. {ECO:0000250, ECO:0000269|PubMed:10817758, ECO:0000269|PubMed:11698476, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:14718551, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19483673}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 152/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	4/28
blood	8/28
bone	10/26
breast	11/33
central nervous system	14/56
cervix	0/4
colorectal	4/17
esophagus	0/13
fibroblast	1/1
gastric	1/16
kidney	2/21
liver	4/20
lung	17/75
lymphocyte	2/16
ovary	3/26
pancreas	3/24
peripheral nervous system	5/16
plasma cell	8/15
prostate	1/1
skin	9/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	2/29
uterus	1/5

Expression Distribution

CRD-mediated mRNA stabilization
CRD-mediated mRNA stability complex
histone pre-mRNA 3end processing complex
protein localization to cytoplasmic stress granule
U12-type spliceosomal complex
GTPase binding
mRNA stabilization
RNA stabilization
negative regulation of mRNA catabolic process
negative regulation of RNA catabolic process
cytoplasmic stress granule
negative regulation of mRNA metabolic process
positive regulation of cell division
double-stranded DNA binding
single-stranded DNA binding
Notch signaling pathway
ribonucleoprotein complex
regulation of cell division
regulation of mRNA stability
regulation of RNA stability
regulation of mRNA catabolic process
nuclear membrane
negative regulation of cellular catabolic process
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
negative regulation of catabolic process
regulation of mRNA metabolic process
RNA splicing
DNA-binding transcription activator activity, RNA polymerase II-specific
mRNA processing
transcription by RNA polymerase II
RNA polymerase II proximal promoter sequence-specific DNA binding
posttranscriptional regulation of gene expression
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA-binding transcription factor activity
intracellular membrane-bounded organelle
mRNA metabolic process