ZC3H14

Entrez Summary: The protein encoded by this gene is a poly(A)-binding protein that can affect gene expression and poly(A) tail length. The encoded protein may influence mRNA stability, nuclear export, and translation. [provided by RefSeq, May 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of mRNA polyadenylation
negative regulation of mRNA 3-end processing
regulation of mRNA polyadenylation
poly(A) binding
regulation of mRNA 3-end processing
negative regulation of mRNA processing
dendrite cytoplasm
axon cytoplasm
negative regulation of mRNA metabolic process
regulation of mRNA processing
ribonucleoprotein complex
regulation of mRNA stability
regulation of RNA stability
regulation of mRNA catabolic process
regulation of mRNA metabolic process
nuclear speck
posttranscriptional regulation of gene expression
regulation of cellular catabolic process
nucleolus
regulation of catabolic process
negative regulation of RNA metabolic process
RNA binding
negative regulation of nucleobase-containing compound metabolic process
negative regulation of gene expression