ZDHHC5

Entrez Summary: N/A
UniProt Summary: Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity). {ECO:0000250, ECO:0000269|PubMed:21820437}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
FK-506 5μM R07 exp358	-2.56
Ibrutinib 1μM R07 exp372	-2.12
Ethanol 0.01 R05 exp234	-2.11
Dynasore 7μM R08 exp436	-2.04
Salubrinal 20μM R07 exp399	-1.99
Sulforaphane 9μM R08 exp525	-1.92
Sulforaphane 9μM R08 exp526 no dilution day6	-1.9
Bortezomib 0.005μM R00 exp6	-1.76
Q15 2.7μM R02 exp79	-1.74
Citral 50μM R06 exp274	-1.73
QNZ 0.01μM R08 exp439	-1.73
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-1.72
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.73
MS094 2μM R03 exp136	1.76
Colchicine 0.009μM R05 exp215	1.78
Etoposide 1μM R00 exp19	1.85
Actinomycin-D 0.001μM R00 exp3	1.99
Rotenone 20μM R00 exp34	2.05

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

palmitoyltransferase activity
protein-cysteine S-palmitoyltransferase activity
protein palmitoylation
protein lipidation
lipoprotein biosynthetic process
lipoprotein metabolic process
protein acylation
dendrite
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
membrane