ZMYM2

Entrez Summary: The protein encoded by this gene is a zinc finger protein that may act as a transcription factor. The encoded protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Thapsigargin 0.005μM R07 exp407	-2.46
Asunaprenir 3μM R07 exp336	-2.44
Dimethyloxaloylglycine 100μM R05 exp229	-2.26
Lead acetate 2000μM R08 exp497	-2.24
LB-100 2μM R05 exp210	-2.2
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-2.16
Tunicamycin 0.04μM R07 exp418	-2.04
MK2206 4μM R08 exp504	-1.99
All-trans-Retinoic-Acid 8μM R07 exp333	-1.92
Senexin-A 25μM R07 exp400	-1.91
Radicicol 0.16μM R05 exp242	-1.9
Lenalidomide 20μM R07 exp375	-1.86
Deguelin 0.15μM R05 exp209	-1.83
Tenofovir 10μM R07 exp405	-1.82
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-1.8
Disulfiram 4.3μM R06 exp281	-1.76
PFI-3 10μM R03 exp144	-1.75
Zebularine 20μM R07 exp423	-1.73
Bortezomib 0.05μM R00 exp7	1.78
LY2090314 0.003μM R08 exp500 no dilution day6	1.79
JQ1 0.8μM R08 exp435	1.82
BVD-523 15μM R02 exp67	1.9
Atovaquone 15μM R08 exp451	1.92
LY2090314 0.003μM R08 exp499	2.05
UMK57 1μM R01 exp59	2.2
UM131593 0.2μM R03 exp106	2.45

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DUF3504
zf-FCS

ubiquitin conjugating enzyme binding
PML body
regulation of cell morphogenesis
zinc ion binding
regulation of anatomical structure morphogenesis
DNA-binding transcription factor activity, RNA polymerase II-specific