ZNF675
Gene Information
- Official Symbol: ZNF675
- Official Name: zinc finger protein 675
- Aliases and Previous Symbols: N/A
- Entrez ID: 171392
- UniProt: Q8TD23
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May be involved in transcriptional regulation. May play a role during osteoclast differentiation by modulating TRAF6 signaling activity.
Pfam Domains GO Terms
Pfam Domains
| KRAB |
| zf-C2H2 |
GO Terms
| negative regulation of interleukin-1-mediated signaling pathway |
| regulation of interleukin-1-mediated signaling pathway |
| negative regulation of JUN kinase activity |
| negative regulation of tumor necrosis factor-mediated signaling pathway |
| negative regulation of transcription regulatory region DNA binding |
| bone resorption |
| negative regulation of osteoclast differentiation |
| negative regulation of JNK cascade |
| negative regulation of stress-activated MAPK cascade |
| negative regulation of stress-activated protein kinase signaling cascade |
| negative regulation of myeloid leukocyte differentiation |
| bone remodeling |
| regulation of transcription regulatory region DNA binding |
| negative regulation of DNA binding |
| regulation of tumor necrosis factor-mediated signaling pathway |
| negative regulation of cytokine-mediated signaling pathway |
| negative regulation of response to cytokine stimulus |
| regulation of osteoclast differentiation |
| I-kappaB kinase/NF-kappaB signaling |
| negative regulation of MAP kinase activity |
| negative regulation of myeloid cell differentiation |
| negative regulation of NF-kappaB transcription factor activity |
| regulation of JUN kinase activity |
| negative regulation of leukocyte differentiation |
| tissue remodeling |
| regulation of myeloid leukocyte differentiation |
| regulation of DNA binding |
| negative regulation of protein serine/threonine kinase activity |
| negative regulation of hemopoiesis |
| negative regulation of DNA-binding transcription factor activity |
| regulation of cytokine-mediated signaling pathway |
| negative regulation of MAPK cascade |
| negative regulation of binding |
| regulation of response to cytokine stimulus |
| regulation of JNK cascade |
| tissue homeostasis |
| negative regulation of protein kinase activity |
| regulation of myeloid cell differentiation |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| negative regulation of kinase activity |
| regulation of leukocyte differentiation |
| negative regulation of transferase activity |
| ubiquitin protein ligase binding |
| multicellular organismal homeostasis |
| anatomical structure homeostasis |
| regulation of MAP kinase activity |
| regulation of binding |
| negative regulation of protein phosphorylation |
| regulation of DNA-binding transcription factor activity |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| regulation of hemopoiesis |
| negative regulation of intracellular signal transduction |
| regulation of protein serine/threonine kinase activity |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of protein modification process |
| cytokine-mediated signaling pathway |
| perinuclear region of cytoplasm |
| negative regulation of cell differentiation |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| zinc ion binding |
| negative regulation of transcription by RNA polymerase II |
| regulation of kinase activity |
| negative regulation of developmental process |
| regulation of transferase activity |
| cellular response to cytokine stimulus |
| negative regulation of cellular protein metabolic process |
| response to cytokine |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| homeostatic process |
| regulation of immune system process |
| intracellular signal transduction |
| negative regulation of gene expression |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2339
- Expression level (log2 read counts): 5.58
Expression Distribution
ZNF675 Expression in NALM6 Cells: 5.58
