FAM60A

Entrez Summary: N/A
UniProt Summary: Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway (PubMed:22865885, PubMed:22984288). Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming (By similarity). {ECO:0000250|UniProtKB:Q8C8M1, ECO:0000269|PubMed:22865885, ECO:0000269|PubMed:22984288}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cabazitaxel 0.001μM R05 exp223	-2.2
Wortmannin 0.5μM R00 exp37	-2.02
UNC2400 2μM R03 exp156	-1.97
5-Fluorouracil 2μM R00 exp1	-1.91
Dimethyloxaloylglycine 11μM R07 exp314	-1.75
Wortmannin 5μM R00 exp38	-1.75
Senexin-A 25μM R07 exp400	-1.73
Ammonium tetrathiomolybdate 10μM R08 exp448	1.77
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.78
JQ1 0.8μM R08 exp435	1.8
Ethanol 0.01 R05 exp234	1.82
THZ531 0.11 to 0.175μM on day4 R07 exp413	1.98
LY2090314 0.003μM R08 exp500 no dilution day6	2.22
ML-792 0.2μM R08 exp505	3.59
THZ531 0.225μM R08 exp444	3.94

Global Fraction of Cell Lines Where Essential: 21/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	2/28
bone	0/25
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	1/20
lung	3/75
lymphocyte	0/14
ovary	2/26
pancreas	0/24
peripheral nervous system	4/16
plasma cell	0/15
prostate	0/1
skin	3/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	1/5

Expression Distribution