LUC7L2

Entrez Summary: This gene encodes a protein that contains a C2H2-type zinc finger, coiled-coil region and arginine, serine-rich (RS) domain. A similar protein in mouse interacts with sodium channel modifier 1, and the encoded protein may be involved in the recognition of non-consensus splice donor sites in association with the U1 snRNP spliceosomal subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011].
UniProt Summary: May bind to RNA via its Arg/Ser-rich domain.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nifuroxazide 5μM R03 exp102	-3.23
Colchicine 0.009μM R05 exp215	-2.79
TNF-alpha 44ng/ml R08 exp533	-2.28
Etoposide 0.1μM R05 exp198	-2.2
MLN-4924 0.2μM R00 exp21	-2.18
Oligomycin-A 2μM R00 exp25	-2.14
Rapamycin 0.001μM R08 exp429	-2.14
UM0131023 0.05μM R05 exp248	-1.94
Vemurafenib 6.6μM R02 exp89	-1.87
Thalidomide 20μM R07 exp406	-1.86
L-74142 5μM R03 exp131	-1.76
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-1.75
Chlorpromazine 10μM R07 exp344	-1.73
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-1.72
2-Methoxyestradiol 0.2μM R01 exp40	-1.71
PFI-3 10μM R03 exp144	-1.7
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.7
THZ1 0.06μM R08 exp531	-1.7
2-Deoxy-D-glucose 800μM R05 exp214	1.73
CFI-400945 25μM R08 exp469	1.82
CB-5083 0.4μM R08 exp468	2.02
UM0125461 0.74μM R02 exp84	2.51

Global Fraction of Cell Lines Where Essential: 9/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	1/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	2/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution