NHLRC2

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Chlorpromazine 10μM R07 exp344	-2.34
Betulinic acid 10 to 15μM on day4 R05 exp222	-2.21
ML-792 0.2μM R08 exp505	-2.2
UMK57 0.6μM R03 exp107	-2.16
Chloramphenicol 2μM R00 exp12	-2.13
Deguelin 0.05μM R02 exp69	-2.11
Pifithrin-alpha 20μM R07 exp390	-2.1
BAY-598 4μM R05 exp220	-2.05
Golgicide-A 4μM R03 exp122	-1.93
Quercetin 20μM R08 exp517	-1.92
SGC0946 7μM R03 exp151	-1.9
CCCP 0.1μM R00 exp10	-1.85
Metformin 100 to 150μM on day4 R04 exp170	-1.81
Rapamycin 2μM R07 exp306	-1.81
Trichostatin-A 0.06μM R07 exp415	-1.81
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-1.76
Hypoxia 5%O2 R04 exp191	-1.74
MK2206 4μM R08 exp504	-1.7
UNC1999 2μM R03 exp155	-1.7
Cytochalasin-B 5μM R07 exp349	1.71
HMS-I1 10μM R06 exp256	1.96
Latrunculin-B 10μM R07 exp374	2.09

Global Fraction of Cell Lines Where Essential: 397/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	15/28
blood	12/28
bone	11/26
breast	13/33
central nervous system	39/56
cervix	3/4
colorectal	7/17
esophagus	4/13
fibroblast	1/1
gastric	10/16
kidney	12/21
liver	14/20
lung	41/75
lymphocyte	3/16
ovary	8/26
pancreas	13/24
peripheral nervous system	13/16
plasma cell	8/15
prostate	1/1
skin	18/24
soft tissue	6/9
thyroid	2/2
upper aerodigestive	7/22
urinary tract	17/29
uterus	2/5

Expression Distribution