SULT1A3
Gene Information
- Official Symbol: SULT1A3
- Official Name: sulfotransferase family 1A member 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 6818
- UniProt: P0DMM9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.
Pfam Domains GO Terms
Pfam Domains
| Sulfotransfer 1 |
GO Terms
| amine sulfotransferase activity |
| NMDA selective glutamate receptor signaling pathway |
| sulfate binding |
| aryl sulfotransferase activity |
| dopamine catabolic process |
| catechol-containing compound catabolic process |
| catecholamine catabolic process |
| ethanol catabolic process |
| phenol-containing compound catabolic process |
| calcineurin-mediated signaling |
| primary alcohol catabolic process |
| flavonoid metabolic process |
| sulfation |
| ethanol metabolic process |
| 3-phosphoadenosine 5-phosphosulfate metabolic process |
| ionotropic glutamate receptor signaling pathway |
| purine ribonucleoside bisphosphate metabolic process |
| ERK1 and ERK2 cascade |
| dopamine metabolic process |
| sulfotransferase activity |
| dopamine receptor signaling pathway |
| catecholamine metabolic process |
| catechol-containing compound metabolic process |
| glutamate receptor signaling pathway |
| antibiotic catabolic process |
| alcohol catabolic process |
| IRE1-mediated unfolded protein response |
| organic hydroxy compound catabolic process |
| primary alcohol metabolic process |
| phenol-containing compound metabolic process |
| cellular response to dopamine |
| response to dopamine |
| signal transduction involved in cellular response to ammonium ion |
| cellular response to catecholamine stimulus |
| cellular response to monoamine stimulus |
| antibiotic metabolic process |
| endoplasmic reticulum unfolded protein response |
| response to monoamine |
| response to catecholamine |
| cellular response to unfolded protein |
| cellular response to ammonium ion |
| xenobiotic metabolic process |
| ribonucleoside bisphosphate metabolic process |
| nucleoside bisphosphate metabolic process |
| purine nucleoside bisphosphate metabolic process |
| drug catabolic process |
| calcium-mediated signaling |
| cellular response to topologically incorrect protein |
| response to unfolded protein |
| response to ammonium ion |
| cellular response to xenobiotic stimulus |
| response to topologically incorrect protein |
| ammonium ion metabolic process |
| negative regulation of neuron death |
| response to endoplasmic reticulum stress |
| steroid metabolic process |
| response to xenobiotic stimulus |
| regulation of neuron death |
| purine ribonucleotide metabolic process |
| alcohol metabolic process |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| second-messenger-mediated signaling |
| sulfur compound metabolic process |
| purine-containing compound metabolic process |
| MAPK cascade |
| signal transduction by protein phosphorylation |
| cellular response to drug |
| small molecule catabolic process |
| aromatic compound catabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| organic hydroxy compound metabolic process |
| organic cyclic compound catabolic process |
| drug metabolic process |
| nucleobase-containing small molecule metabolic process |
| cellular response to organic cyclic compound |
| cellular response to organonitrogen compound |
| cellular response to nitrogen compound |
| organophosphate metabolic process |
| response to organic cyclic compound |
| protein phosphorylation |
| negative regulation of cell death |
| response to organonitrogen compound |
| oxoacid metabolic process |
| response to drug |
| organic acid metabolic process |
| carbohydrate derivative metabolic process |
| cellular response to oxygen-containing compound |
| organonitrogen compound catabolic process |
| response to nitrogen compound |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| phosphorylation |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| small molecule metabolic process |
| organic substance catabolic process |
| cellular catabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.57 |
| TCEB3CL2 | 0.468 |
| AATF | 0.46 |
| TWISTNB | 0.454 |
| TCEB3CL | 0.448 |
| TBC1D3H | 0.445 |
| TBC1D3E | 0.445 |
| TBC1D3I | 0.445 |
| TBC1D3K | 0.444 |
| TBC1D3L | 0.444 |
| TBC1D3G | 0.441 |
| TCEB3C | 0.441 |
| TBC1D3F | 0.438 |
| POLR2D | 0.437 |
| SLC6A17 | 0.436 |
| DDTL | 0.436 |
| CHD4 | 0.434 |
| PAN2 | 0.432 |
| PSMD3 | 0.431 |
| PSMB4 | 0.429 |
| RPS2 | 0.429 |
| PSMD11 | 0.428 |
| SLC38A7 | 0.426 |
| COPG1 | 0.425 |
| ORC1 | 0.425 |
| PSMB2 | 0.425 |
| TBC1D3 | 0.418 |
| PSMD2 | 0.418 |
| EXOSC5 | 0.416 |
| POLR2J3 | 0.414 |
| TP53TG3D | 0.414 |
| UPF1 | 0.414 |
| TBC1D3C | 0.413 |
| PWP2 | 0.412 |
| VASN | 0.412 |
| FCN2 | 0.411 |
| PSMC2 | 0.409 |
| VPS28 | 0.409 |
| BYSL | 0.406 |
| C1QTNF9B | 0.406 |
| PSMA6 | 0.406 |
| POLA1 | 0.405 |
| RPS19 | 0.403 |
| PRIM1 | 0.402 |
| SYT9 | 0.402 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: N/A
| Tissue | Fraction Of Cell Lines Where Essential |
|---|
Essentiality in NALM6
- Essentiality Rank: 2723
- Expression level (log2 read counts): 3.4
Expression Distribution
SULT1A3 Expression in NALM6 Cells: 3.4
