UBE2M
Gene Information
- Official Symbol: UBE2M
- Official Name: ubiquitin conjugating enzyme E2 M
- Aliases and Previous Symbols: N/A
- Entrez ID: 9040
- UniProt: P61081
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Accepts the ubiquitin-like protein NEDD8 from the UBA3- NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation. {ECO:0000269|PubMed:10207026, ECO:0000269|PubMed:15361859}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 629
- Expression level (log2 read counts): 5.62
UBE2M Expression in NALM6 Cells: 5.62
