UBE3D

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. {ECO:0000269|PubMed:15749827}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Trimetrexate 0.03μM R08 exp535	-2.89
Hydroxyurea 15μM R06 exp289	-2.56
Hydroxyurea 100μM R07 exp329	-2.54
Nifuroxazide 1μM R01 exp51	-2.51
YM155 0.001μM R08 exp432	-2.28
Menadione 5μM R06 exp292	-2.18
Talazoparib 0.006μM R06 exp299	-2.14
Hypoxia 5%O2 R04 exp191	-2.03
L-BMAA 500 to 750μM on day4 R04 exp185	-1.92
UM0131023 0.05μM R05 exp248	-1.86
NFN1 1μM R03 exp100	-1.84
Trientine 500μM R08 exp534	-1.83
BAY-598 4μM R05 exp220	-1.77
CCT251545 20μM R07 exp326	-1.71
∆-9-Tetrahydrocannabinol 30μM R08 exp445	1.72
Dimethyl-Sulfoxide 1pc R03 exp120	1.94
Rapamycin 10μM R00 exp30	1.94
Pyridostatin 4μM R05 exp240	1.96
MLN-4924 2μM R00 exp22	2.12
Etoposide 0.1μM R05 exp198	2.44
Golgicide-A 4μM R03 exp122	2.46
Doxorubicin 0.02μM R08 exp478	2.64

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution