ANAPC11

Entrez Summary: N/A
UniProt Summary: Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. {ECO:0000269|PubMed:11739784, ECO:0000269|PubMed:18485873}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Sulforaphane 9μM R08 exp525	-2.35
Hippuristanol 0.12μM R08 exp489 no dilution day6	-2.21
Sulforaphane 9μM R08 exp526 no dilution day6	-2.11
Wortmannin 0.5μM R00 exp37	-2.11
Talazoparib 0.006μM R06 exp299	-1.98
Curcumin 6.5μM R06 exp277	-1.91
Amiloride 100μM R08 exp447	-1.89
Tozasertib 0.1μM R07 exp414	-1.89
LLY-284 2.6μM R06 exp291	-1.88
MK-1775 0.32μM R02 exp75	-1.86
LB-100 2μM R05 exp210	-1.81
Hydroxyurea 15μM R06 exp289	-1.79
35°C R06 exp302	-1.74
ABT-702 0.1μM R06 exp260	-1.73
Phenformin 20μM R03 exp143	-1.73
Trimetrexate 0.03μM R08 exp535	-1.73
6-Thio-2-deoxyguanosine 2μM R06 exp259	-1.71
Actinomycin-D 0.01μM R00 exp4	1.89

Global Fraction of Cell Lines Where Essential: 739/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution