ATP6V1D

Entrez Summary: N/A
UniProt Summary: Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. {ECO:0000250, ECO:0000269|PubMed:21844891}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Clomiphene 4.4μM R02 exp68	-3.05
Etoposide 0.3μM R05 exp199	-2.45
Nocodazole 0.2μM R00 exp24	-2.41
Cryptotanshinone 12μM R05 exp227	-2.3
Bortezomib 0.05μM R00 exp7	-2.23
Salubrinal 20μM R07 exp399	-2.23
Bafilomycin-A1 0.009μM R08 exp454	-2.15
DABN 20μM R00 exp17	-2.12
Pyronaridine 1μM R06 exp295	-2.08
WNT3A 44ng/ml R08 exp537	-2.08
Sulforaphane 9μM R08 exp526 no dilution day6	-2.02
Etoposide 1μM R00 exp19	-2.01
Vemurafenib 6.6μM R02 exp89	-1.95
Hydroxyurea 100μM R07 exp329	-1.93
Cerivastatin 0.15μM R05 exp226	-1.88
Dimethyloxaloylglycine 11μM R07 exp314	-1.87
Pyridostatin 4μM R05 exp240	-1.86
Tanespimycin 14μM R08 exp527	-1.84
All-trans-Retinoic-Acid 40μM R07 exp334	-1.83
Bisphenol A 100μM R06 exp269	-1.77
Dimethyloxaloylglycine 100μM R05 exp229	-1.77
PU-H71 1μM R08 exp515	-1.76
EPZ-5676 30μM R05 exp233	-1.72
Taxol 0.004μM R03 exp103	-1.72
Tozasertib 0.1μM R07 exp414	-1.72
PFI-3 10μM R03 exp144	2.09

Global Fraction of Cell Lines Where Essential: 108/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	3/28
bone	3/26
breast	4/33
central nervous system	3/56
cervix	1/4
colorectal	3/17
esophagus	1/13
fibroblast	0/1
gastric	4/16
kidney	7/21
liver	4/20
lung	8/75
lymphocyte	0/16
ovary	7/26
pancreas	5/24
peripheral nervous system	3/16
plasma cell	6/15
prostate	0/1
skin	5/24
soft tissue	2/9
thyroid	1/2
upper aerodigestive	2/22
urinary tract	4/29
uterus	0/5

Expression Distribution