CHD7

Entrez Summary: This gene encodes a protein that contains several helicase family domains. Mutations in this gene have been found in some patients with the CHARGE syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-D1870 2μM R04 exp162	-2.11
Lead acetate 2000μM R08 exp497	-2.1
Lead acetate 2000μM R08 exp498 no dilution day6	-1.98
THZ531 0.11μM R07 exp409	-1.86
CCT251545 0.2μM R06 exp271	-1.77
Cerivastatin 0.15μM R05 exp226	-1.72
Cyclosporin-A 0.8μM R07 exp347	-1.72
Etoposide 0.3μM R05 exp199	1.81
Diepoxybutane 3μM R07 exp354	1.82
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.85
THZ1 0.06μM R08 exp531	1.94
Etoposide 1μM R00 exp19	2
Rotenone 20μM R00 exp34	2.01
Etoposide 10μM R00 exp20	2.02
5-Fluorouracil 20μM R00 exp2	2.04
FTY720 3μM R08 exp483	2.08
Latrunculin-B 10μM R07 exp374	2.12
Doxorubicin 0.02μM R08 exp478	2.14
Bafilomycin-A1 0.009μM R08 exp454	2.26
Cannabidiol 20μM R08 exp466	2.36
Taxol 0.004μM R03 exp103	2.51
Thapsigargin 0.005μM R07 exp407	2.88
Actinomycin-D 0.001μM R00 exp3	3.35
TRAIL 5ng/ml R00 exp35	4.89
TRAIL 50ng/ml R00 exp36	5.56

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution