CNOT4
Gene Information
- Official Symbol: CNOT4
- Official Name: CCR4-NOT transcription complex subunit 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 4850
- UniProt: O95628
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| CCR4-NOT complex |
| nuclear-transcribed mRNA poly(A) tail shortening |
| regulation of megakaryocyte differentiation |
| DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| intracellular signal transduction involved in G1 DNA damage checkpoint |
| signal transduction involved in mitotic DNA integrity checkpoint |
| signal transduction involved in mitotic DNA damage checkpoint |
| signal transduction involved in mitotic cell cycle checkpoint |
| signal transduction involved in mitotic G1 DNA damage checkpoint |
| nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| mitotic G1 DNA damage checkpoint |
| mitotic G1/S transition checkpoint |
| G1 DNA damage checkpoint |
| protein autoubiquitination |
| signal transduction involved in DNA damage checkpoint |
| signal transduction involved in DNA integrity checkpoint |
| signal transduction involved in cell cycle checkpoint |
| DNA damage response, signal transduction by p53 class mediator |
| positive regulation of cell cycle arrest |
| mitotic DNA damage checkpoint |
| negative regulation of G1/S transition of mitotic cell cycle |
| mitotic DNA integrity checkpoint |
| signal transduction in response to DNA damage |
| negative regulation of cell cycle G1/S phase transition |
| regulation of cell cycle arrest |
| signal transduction by p53 class mediator |
| DNA damage checkpoint |
| DNA integrity checkpoint |
| regulation of G1/S transition of mitotic cell cycle |
| mitotic cell cycle checkpoint |
| regulation of cell cycle G1/S phase transition |
| cell cycle checkpoint |
| nuclear-transcribed mRNA catabolic process |
| negative regulation of mitotic cell cycle phase transition |
| mRNA catabolic process |
| regulation of myeloid cell differentiation |
| negative regulation of cell cycle phase transition |
| ubiquitin-protein transferase activity |
| RNA catabolic process |
| positive regulation of cell cycle process |
| negative regulation of mitotic cell cycle |
| negative regulation of cell cycle process |
| nucleobase-containing compound catabolic process |
| positive regulation of cell cycle |
| regulation of mitotic cell cycle phase transition |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| regulation of cell cycle phase transition |
| regulation of hemopoiesis |
| organic cyclic compound catabolic process |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| negative regulation of cell cycle |
| proteolysis involved in cellular protein catabolic process |
| mitotic cell cycle process |
| cellular protein catabolic process |
| regulation of mitotic cell cycle |
| mitotic cell cycle |
| protein catabolic process |
| protein ubiquitination |
| mRNA metabolic process |
| regulation of cell cycle process |
| protein modification by small protein conjugation |
| cellular response to DNA damage stimulus |
| cellular macromolecule catabolic process |
| protein modification by small protein conjugation or removal |
| cell cycle process |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| regulation of cell cycle |
| proteolysis |
| cell cycle |
| RNA binding |
| regulation of immune system process |
| RNA metabolic process |
| intracellular signal transduction |
| cellular response to stress |
| negative regulation of gene expression |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13789
- Expression level (log2 read counts): 4.7
Expression Distribution
CNOT4 Expression in NALM6 Cells: 4.7
