COL4A3BP
Gene Information
- Official Symbol: CERT1
- Official Name: ceramide transporter 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 10087
- UniProt: Q9Y5P4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| PH |
| START |
GO Terms
| intermembrane sphingolipid transfer |
| ceramide transfer activity |
| ceramide binding |
| ER to Golgi ceramide transport |
| ceramide 1-phosphate binding |
| ceramide 1-phosphate transport |
| ceramide 1-phosphate transfer activity |
| intermembrane lipid transfer |
| ceramide transport |
| mitochondrion morphogenesis |
| phosphatidylinositol-4-phosphate binding |
| intracellular lipid transport |
| endoplasmic reticulum organization |
| kinase activity |
| ceramide metabolic process |
| sphingolipid biosynthetic process |
| phospholipid transport |
| organophosphate ester transport |
| membrane lipid biosynthetic process |
| lipid homeostasis |
| sphingolipid metabolic process |
| lipid binding |
| membrane lipid metabolic process |
| muscle contraction |
| heart morphogenesis |
| response to endoplasmic reticulum stress |
| lipid transport |
| muscle system process |
| lipid localization |
| in utero embryonic development |
| endomembrane system organization |
| mitochondrion organization |
| organic anion transport |
| cell part morphogenesis |
| heart development |
| cell population proliferation |
| lipid biosynthetic process |
| anion transport |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| perinuclear region of cytoplasm |
| cell morphogenesis |
| cellular amide metabolic process |
| cellular component morphogenesis |
| membrane organization |
| circulatory system development |
| endoplasmic reticulum membrane |
| cellular lipid metabolic process |
| animal organ morphogenesis |
| embryo development |
| Golgi apparatus |
| chemical homeostasis |
| lipid metabolic process |
| mitochondrion |
| phosphorylation |
| ion transport |
| organonitrogen compound biosynthetic process |
| intracellular transport |
| amide transport |
| homeostatic process |
| cellular response to stress |
| establishment of localization in cell |
| nitrogen compound transport |
| immune response |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| BH1 1μM R04 exp169 | -3.91 |
| Clomiphene 4.4μM R02 exp68 | -3.52 |
| Q15 2.7μM R02 exp79 | -2.62 |
| Q15 1 to 2μM on day4 R04 exp164 | -2.46 |
| Azithromycin 100μM R08 exp452 | -2.38 |
| Momordin-Ic 10μM R08 exp506 | -2.34 |
| Vincristine 0.0005μM R04 exp190 | -2.26 |
| Vemurafenib 6.6μM R02 exp89 | -2.24 |
| WYE-354 6μM R02 exp90 | -2.23 |
| Vemurafenib 6.6μM R08 exp434 | -2.22 |
| 3-Bromopyruvate 7μM R04 exp175 | -2.21 |
| CFI-400945 25μM R08 exp469 | -1.86 |
| MK2206 4μM R08 exp504 | -1.75 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 1/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11439
- Expression level (log2 read counts): 5.71
Expression Distribution
COL4A3BP Expression in NALM6 Cells: 5.71
