DAGLB
Gene Information
- Official Symbol: DAGLB
- Official Name: diacylglycerol lipase beta
- Aliases and Previous Symbols: N/A
- Entrez ID: 221955
- UniProt: Q8NCG7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Lipase 3 |
GO Terms
| endocannabinoid signaling pathway |
| retrograde trans-synaptic signaling by lipid |
| retrograde trans-synaptic signaling by endocannabinoid |
| diacylglycerol catabolic process |
| cannabinoid signaling pathway |
| trans-synaptic signaling by endocannabinoid |
| trans-synaptic signaling by lipid |
| retrograde trans-synaptic signaling |
| G protein-coupled glutamate receptor signaling pathway |
| diacylglycerol metabolic process |
| neuroblast proliferation |
| acylglycerol catabolic process |
| neutral lipid catabolic process |
| neurotransmitter biosynthetic process |
| glutamate receptor signaling pathway |
| glycerolipid catabolic process |
| stem cell proliferation |
| arachidonic acid metabolic process |
| neural precursor cell proliferation |
| hydrolase activity |
| neurotransmitter metabolic process |
| acylglycerol metabolic process |
| neutral lipid metabolic process |
| unsaturated fatty acid metabolic process |
| icosanoid metabolic process |
| long-chain fatty acid metabolic process |
| fatty acid derivative metabolic process |
| cellular lipid catabolic process |
| postsynaptic membrane |
| lipid catabolic process |
| lysosomal membrane |
| fatty acid metabolic process |
| regulation of neurotransmitter levels |
| glycerolipid metabolic process |
| trans-synaptic signaling |
| synaptic signaling |
| monocarboxylic acid metabolic process |
| cell population proliferation |
| carboxylic acid metabolic process |
| cellular lipid metabolic process |
| oxoacid metabolic process |
| organic acid metabolic process |
| cell-cell signaling |
| lipid metabolic process |
| G protein-coupled receptor signaling pathway |
| generation of neurons |
| neurogenesis |
| small molecule metabolic process |
| organic substance catabolic process |
| cellular catabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12073
- Expression level (log2 read counts): 6.92
Expression Distribution
DAGLB Expression in NALM6 Cells: 6.92
