ESCO2
Gene Information
- Official Symbol: ESCO2
- Official Name: establishment of sister chromatid cohesion N-acetyltransferase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 157570
- UniProt: Q56NI9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein that may have acetyltransferase activity and may be required for the establishment of sister chromatid cohesion during the S phase of mitosis. Mutations in this gene have been associated with Roberts syndrome. [provided by RefSeq, Jul 2008].
- UniProt Summary: Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3. {ECO:0000269|PubMed:15821733, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4866
- Expression level (log2 read counts): 6.09
ESCO2 Expression in NALM6 Cells: 6.09
