HAT1

Entrez Summary: N/A
UniProt Summary: Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage. {ECO:0000269|PubMed:11585814, ECO:0000269|PubMed:20953179, ECO:0000269|PubMed:22615379, ECO:0000269|PubMed:9427644}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-2536 0.0042μM R03 exp95	-2.19
Parthenolide 2.5μM R05 exp238	-1.88
Curcumin 6.5μM R06 exp277	-1.72
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	1.71
Trimetrexate 0.03μM R08 exp535	1.75
Ibrutinib 10μM R08 exp442	1.76
NN-Diethyl-meta-toluamide 500μM R08 exp438	1.84
Betulinic acid 10 to 15μM on day4 R05 exp222	1.88
Lead acetate 2000μM R08 exp498 no dilution day6	1.88
B02 10μM R08 exp453	1.94
ZLN024 50μM R08 exp538	1.99
HMS-I2 10μM R06 exp288	2
Trichostatin-A 0.06μM R07 exp415	2.03
Hypoxia 5%O2 R04 exp191	2.06
Cincreasin 100μM R08 exp473	2.11
RS-1 10μM R08 exp519	2.3
Bortezomib 0.005μM R00 exp6	2.73

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution