LIN9

Entrez Summary: N/A
UniProt Summary: Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. {ECO:0000269|PubMed:15538385, ECO:0000269|PubMed:16730350}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Docetaxel 0.002μM R01 exp45	-2.35
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-2.32
Etoposide 0.1μM R05 exp198	-2.32
Lapatinib 5μM R01 exp47	-2.27
Artemisinin 50μM R08 exp450	-2.04
S-DABN 8μM R03 exp112	-2.03
Vincristine 0.0005μM R04 exp190	-1.96
QNZ 0.01μM R08 exp439	-1.92
Colchicine 0.009μM R05 exp215	-1.91
Dexamethasone 0.006μM R07 exp351	-1.91
S-trityl-L-cysteine 0.5μM R05 exp243	-1.89
Taxol 0.002μM R01 exp54	-1.89
Epothilone-B 0.0015μM R05 exp231	-1.83
Trientine 500μM R08 exp534	-1.81
Chloramphenicol 20μM R00 exp13	-1.8
Aminopterin 0.005μM R07 exp335	1.75
Curcumin 6.5μM R06 exp277	1.77
Heregulin-B 44ng/ml R08 exp486	1.92
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	1.99
35°C R06 exp302	2.03
VER-155008 3.9μM R06 exp301	2.07
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	2.35

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution