NOSIP

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813). {ECO:0000250|UniProtKB:Q9D6T0, ECO:0000269|PubMed:11149895, ECO:0000269|PubMed:15548660, ECO:0000269|PubMed:16135813}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bafilomycin-A1 0.009μM R08 exp454	-2.76
Clomiphene 4.4μM R02 exp68	-2.6
Vemurafenib 6.6μM R02 exp89	-2.33
Aminopterin 0.005μM R07 exp335	-2.17
YM155 0.001μM R08 exp432	-2.03
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-1.98
Tubacin 1.6μM R07 exp416	-1.97
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.95
Ethanol 0.01 R05 exp234	-1.94
Dynasore 7μM R08 exp436	-1.91
Oligomycin-A 2μM R00 exp25	-1.88
THZ531 0.11μM R07 exp409	-1.83
Cincreasin 100μM R08 exp473	-1.81
LB-100 2μM R05 exp210	-1.76
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.74
ML-792 0.2μM R08 exp505	-1.72
VER-155008 3.9μM R06 exp301	1.74
2-Deoxy-D-glucose 800μM R05 exp214	1.79
RK-33 8μM R08 exp518	2.14
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.34
Taxol 0.004μM R03 exp103	2.39
Milciclib 2μM R08 exp502	2.6

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution