PDCD5
Gene Information
- Official Symbol: PDCD5
- Official Name: programmed cell death 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 9141
- UniProt: O14737
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May function in the process of apoptosis.
Pfam Domains GO Terms
Pfam Domains
| dsDNA bind |
GO Terms
| positive regulation of protein import into mitochondrial outer membrane |
| negative regulation of chaperone-mediated protein folding |
| regulation of protein import into mitochondrial outer membrane |
| acetyltransferase activator activity |
| regulation of chaperone-mediated protein folding |
| negative regulation of protein folding |
| regulation of protein folding |
| positive regulation of release of cytochrome c from mitochondria |
| positive regulation of protein targeting to mitochondrion |
| beta-tubulin binding |
| positive regulation of protein import |
| regulation of protein targeting to mitochondrion |
| regulation of release of cytochrome c from mitochondria |
| positive regulation of establishment of protein localization to mitochondrion |
| regulation of protein import |
| regulation of establishment of protein localization to mitochondrion |
| regulation of protein targeting |
| positive regulation of mitochondrion organization |
| positive regulation of protein localization to membrane |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| positive regulation of cysteine-type endopeptidase activity |
| positive regulation of intracellular protein transport |
| cellular response to transforming growth factor beta stimulus |
| response to transforming growth factor beta |
| heparin binding |
| positive regulation of endopeptidase activity |
| positive regulation of apoptotic signaling pathway |
| regulation of mitochondrion organization |
| regulation of protein localization to membrane |
| positive regulation of peptidase activity |
| positive regulation of intracellular transport |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of intracellular protein transport |
| regulation of cysteine-type endopeptidase activity |
| positive regulation of cellular protein localization |
| regulation of intracellular transport |
| positive regulation of proteolysis |
| regulation of apoptotic signaling pathway |
| regulation of endopeptidase activity |
| positive regulation of protein transport |
| regulation of peptidase activity |
| positive regulation of establishment of protein localization |
| cellular response to growth factor stimulus |
| response to growth factor |
| regulation of cellular protein localization |
| positive regulation of organelle organization |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| negative regulation of cell population proliferation |
| positive regulation of cell death |
| regulation of protein transport |
| regulation of proteolysis |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| positive regulation of hydrolase activity |
| regulation of cellular localization |
| apoptotic process |
| positive regulation of transport |
| regulation of protein localization |
| programmed cell death |
| cell death |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| regulation of hydrolase activity |
| regulation of organelle organization |
| positive regulation of catalytic activity |
| DNA binding |
| response to endogenous stimulus |
| regulation of apoptotic process |
| regulation of programmed cell death |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of transport |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HARS | 0.578 |
| SSSCA1 | 0.527 |
| VBP1 | 0.515 |
| VEZT | 0.465 |
| TBCB | 0.453 |
| TRIP12 | 0.452 |
| DOHH | 0.449 |
| C15orf41 | 0.439 |
| DHRSX | 0.437 |
| URM1 | 0.435 |
| GEMIN7 | 0.429 |
| THG1L | 0.427 |
| TCP1 | 0.425 |
| ALG13 | 0.422 |
| MSTO1 | 0.42 |
| ZCRB1 | 0.417 |
| ELP3 | 0.417 |
| MRPS5 | 0.416 |
| TMEM242 | 0.416 |
| TSEN54 | 0.414 |
| PPP6C | 0.411 |
| NSD1 | 0.409 |
| PFDN4 | 0.409 |
| TEN1 | 0.408 |
| ELAC2 | 0.407 |
| KIAA0391 | 0.406 |
| DNLZ | 0.405 |
| MRPS14 | 0.405 |
| BCS1L | 0.401 |
| RPTOR | 0.401 |
| PFDN1 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 33/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 2/28 |
| blood | 1/28 |
| bone | 2/26 |
| breast | 0/33 |
| central nervous system | 4/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 1/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 1/20 |
| lung | 4/75 |
| lymphocyte | 1/16 |
| ovary | 1/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 1/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 1/9 |
| thyroid | 0/2 |
| upper aerodigestive | 3/22 |
| urinary tract | 3/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 6266
- Expression level (log2 read counts): 6.08
Expression Distribution
PDCD5 Expression in NALM6 Cells: 6.08
