PSTK

Entrez Summary: N/A
UniProt Summary: Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Palbociclib 1μM R07 exp382	-3.01
Rotenone 2μM R00 exp33	-2.92
UM131593 0.2μM R03 exp106	-2.36
MK2206 4μM R08 exp504	-2.34
HMS-I1 10μM R06 exp256	-2.22
Brefeldin A 0.02μM R00 exp8	-2.19
MLN-4924 0.2μM R00 exp21	-2.11
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-2.02
5-Fluorouracil 20μM R00 exp2	-1.99
BML-284 0.09μM R08 exp460	-1.97
LY2090314 0.003μM R08 exp499	-1.97
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.94
ML-792 0.2μM R08 exp505	-1.91
UM0131023 0.05μM R05 exp248	-1.87
UM0125461 0.74μM R02 exp84	-1.86
Rapamycin 2μM R07 exp306	-1.83
Geldanamycin 0.01μM R05 exp235	-1.81
Thimerosal 0.85μM R08 exp529	-1.81
Dimethyloxaloylglycine 100μM R05 exp229	-1.78
Genistein 15μM R07 exp360	-1.78
INK128 0.2μM R02 exp70	-1.77
Cerivastatin 0.15μM R05 exp226	-1.76
Wortmannin 5μM R00 exp38	-1.76
S-trityl-L-cysteine 0.5μM R05 exp243	-1.75
LY2090314 0.003μM R08 exp500 no dilution day6	-1.73
Phenformin 20μM R03 exp143	-1.72
AICAR 240μM R03 exp116	-1.71
Celastrol 0.12μM R05 exp225	-1.71

Global Fraction of Cell Lines Where Essential: 156/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	8/28
bone	9/26
breast	7/33
central nervous system	20/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	1/1
gastric	0/16
kidney	5/21
liver	7/20
lung	15/75
lymphocyte	7/16
ovary	5/26
pancreas	3/24
peripheral nervous system	6/16
plasma cell	4/15
prostate	0/1
skin	9/24
soft tissue	3/9
thyroid	1/2
upper aerodigestive	0/22
urinary tract	3/29
uterus	1/5

Expression Distribution