STARD3

Entrez Summary: N/A
UniProt Summary: Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263, PubMed:28377464). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (PubMed:28377464). May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (PubMed:12070139, PubMed:19965586). However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:28377464). Does not activate transcriptional cholesterol sensing (PubMed:28377464). Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina (PubMed:21322544). {ECO:0000269|PubMed:11053434, ECO:0000269|PubMed:12070139, ECO:0000269|PubMed:15930133, ECO:0000269|PubMed:19965586, ECO:0000269|PubMed:21322544, ECO:0000269|PubMed:22514632, ECO:0000269|PubMed:24105263, ECO:0000269|PubMed:28377464}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LJH685 50μM R08 exp433	-2.66
Trimetrexate 0.03μM R08 exp535	-2.21
Hypoxia 5%O2 R04 exp191	-2.11
5-Fluorouracil 20μM R00 exp2	-2.1
Resveratrol 16μM R03 exp147	-1.81
Quinacrine 2.5μM R03 exp146	-1.78
UM0125461 0.74μM R02 exp84	-1.77
IL-3 9ng/ml R08 exp493	-1.71
NMS-873 0.07μM R07 exp380	1.77
UM0011500 5μM R05 exp245	1.82
Isoniazid 100μM R08 exp494	1.83
Daidzin 10μM R06 exp280	1.89
Parthenolide 2.5μM R05 exp238	1.89
Fluvastatin 2.2μM R06 exp282	1.98
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	2.44
MK2206 4μM R08 exp504	2.51

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution