TFB2M

Entrez Summary: N/A
UniProt Summary: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity. {ECO:0000269|PubMed:12068295, ECO:0000269|PubMed:12897151, ECO:0000269|PubMed:15526033, ECO:0000269|PubMed:20410300}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.72
Oligomycin-A 2μM R00 exp25	1.82
CoCl2 18μM R07 exp346	2.05
Thimerosal 0.85μM R08 exp529	2.1

Global Fraction of Cell Lines Where Essential: 63/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	1/28
bone	2/26
breast	4/33
central nervous system	2/56
cervix	1/4
colorectal	2/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	4/21
liver	3/20
lung	8/75
lymphocyte	1/16
ovary	2/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	4/22
urinary tract	5/29
uterus	0/5

Expression Distribution