USP27X
Gene Information
- Official Symbol: USP27X
- Official Name: ubiquitin specific peptidase 27 X-linked
- Aliases and Previous Symbols: N/A
- Entrez ID: 389856
- UniProt: A6NNY8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the peptidase protein family. The encoded protein functions as a deubiquitinase that is involved in upregulation of the pro-apoptotic Bim protein. This protein may act as a tumor suppressor by increasing levels of Bim to counteract anti-apoptotic signals in cancer cells. Mutations in this gene have been associated with X-linked cognitive disability. [provided by RefSeq, Dec 2016].
- UniProt Summary: Deubiquitinase that can reduce the levels of BCL2L11/BIM ubiquitination and stabilize BCL2L11 in response to the RAF-MAPK- degradation signal. By acting on BCL2L11 levels, may counteract the anti-apoptotic effects of MAPK activity. {ECO:0000250|UniProtKB:Q8CEG8}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 10925
- Expression level (log2 read counts): 1.55
USP27X Expression in NALM6 Cells: 1.55
