Table of Contents

Curcumin 6.5μM R06 exp277

Mechanism of Action

Component of tumeric spice, many claimed activities but viewed as pan-assay interference compound

Technical Notes

Protein References

  • PubChem Name: Curcumin
  • Synonyms: Turmeric yellow; Natural Yellow 3; Diferuloylmethane
  • CAS #: 458-37-7
  • PubChem CID: 969516
  • IUPAC: (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
  • INCHI Name: InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
  • INCHI Key: VFLDPWHFBUODDF-FCXRPNKRSA-N
  • Molecular Weight: 368.4
  • Canonical SMILES: COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O
  • Isomeric SMILES: COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O
  • Molecular Formula: IC21H20O6

Protein Supplier

  • Supplier Name: Sigma-Aldrich
  • Catalog #: 238384
  • Lot #: CW2318MW

Protein Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C21H20O6 369.13326; found 369.13368

Dose Response Curve

  • Platform ID: Curcumin
  • Min: -8.9938; Max: 98.5043





IC Concentration (µM)
IC10 N/A
IC20 9.9199
IC30 10.6220
IC40 11.2344
IC50 11.8275
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
0/0ScoresViewViewViewViewView