Table of Contents

BRD2 inhibitor II 20μM R07 exp341

Mechanism of Action

Inhibits BRD2, blocks recognition of acetylated H4K12

Technical Notes

Protein References

  • PubChem Name: 1-[2-(1H-Benzimidazol-2-ylsulfanyl)ethyl]-3-methyl-1,3-dihydro-2H-benzimidazole-2-thione
  • Synonyms: N/A
  • CAS #: 433249-32-2
  • PubChem CID: 672548
  • IUPAC: 1-[2-(1H-benzimidazol-2-ylsulfanyl)ethyl]-3-methylbenzimidazole-2-thione
  • INCHI Name: InChI=1S/C17H16N4S2/c1-20-14-8-4-5-9-15(14)21(17(20)22)10-11-23-16-18-12-6-2-3-7-13(12)19-16/h2-9H,10-11H2,1H3,(H,18,19)
  • INCHI Key: KDPSGIFCBZTBEZ-UHFFFAOYSA-N
  • Molecular Weight: 340.5
  • Canonical SMILES: CN1C2=CC=CC=C2N(C1=S)CCSC3=NC4=CC=CC=C4N3
  • Isomeric SMILES: N/A
  • Molecular Formula: C17H16N4S2

Protein Supplier

  • Supplier Name: Calbiochem
  • Catalog #: 203830
  • Lot #: N/A

Protein Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C17H16N4S2 341.08891; found 341.09007

Dose Response Curve

  • Platform ID: BRD2_inhibitor_II
  • Min: -10.0210; Max: 25.0673





IC Concentration (µM)
IC10 N/A
IC20 N/A
IC30 N/A
IC40 N/A
IC50 N/A
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
3/0ScoresViewViewViewViewView