Table of Contents

Deguelin 0.05μM R02 exp69

Mechanism of Action

Derivative of rotenone, putative AKT inhibitor, complex I inhibitor

Technical Notes

Protein References

  • PubChem Name: Deguelin
  • Synonyms: (-)-Deguelin; (-)-cis-Deguelin
  • CAS #: 522-17-8
  • PubChem CID: 107935
  • IUPAC: (1S,14S)-17,18-dimethoxy-7,7-dimethyl-2,8,21-trioxapentacyclo[12.8.0.03,12.04,9.015,20]docosa-3(12),4(9),5,10,15,17,19-heptaen-13-one
  • INCHI Name: InChI=1S/C23H22O6/c1-23(2)8-7-12-15(29-23)6-5-13-21(24)20-14-9-17(25-3)18(26-4)10-16(14)27-11-19(20)28-22(12)13/h5-10,19-20H,11H2,1-4H3/t19-,20+/m1/s1
  • INCHI Key: ORDAZKGHSNRHTD-UXHICEINSA-N
  • Molecular Weight: 394.4
  • Canonical SMILES: CC1(C=CC2=C(O1)C=CC3=C2OC4COC5=CC(=C(C=C5C4C3=O)OC)OC)C
  • Isomeric SMILES: CC1(C=CC2=C(O1)C=CC3=C2O[C@@H]4COC5=CC(=C(C=C5[C@@H]4C3=O)OC)OC)C
  • Molecular Formula: C23H22O6

Protein Supplier

  • Supplier Name: Sigma-Aldrich
  • Catalog #: D0817
  • Lot #: N/A

Protein Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C23H22O6 395.14891; found 395.1502

Dose Response Curve

  • Platform ID: Deguelin
  • Min: -2.5150; Max: 50.5961





IC Concentration (µM)
IC10 N/A
IC20 N/A
IC30 N/A
IC40 N/A
IC50 N/A
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
0/0ScoresViewViewViewViewView