Table of Contents

Bortezomib 0.05μM R00 exp7

Mechanism of Action

Inhibits 26S proteasome, binds reversibly to chymotrypsin-like catalytic sites

Technical Notes

Protein References

  • PubChem Name: Bortezomib
  • Synonyms: PS-341; Brotezamide; DPBA; LDP 341; MG 341; Radiciol; NSC 681239
  • CAS #: 179324-69-7
  • PubChem CID: 387447
  • IUPAC: [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid
  • INCHI Name: InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1
  • INCHI Key: GXJABQQUPOEUTA-RDJZCZTQSA-N
  • Molecular Weight: 384.2
  • Canonical SMILES: B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O
  • Isomeric SMILES: B([C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O
  • Molecular Formula: C19H25BN4O4

Protein Supplier

  • Supplier Name: LC Laboratories
  • Catalog #: B-1408
  • Lot #: BBZ-113

Protein Characterization

  • HRMS (ESI-TOF) m/z: [M+H-H2O]+ Calcd for C19H24BN4O3 367.1936; found 367.1966

Dose Response Curve

  • Platform ID: Bortezomib
  • Min: -9.7617; Max: 99.4238





IC Concentration (µM)
IC10 N/A
IC20 0.0070
IC30 0.0072
IC40 0.0073
IC50 0.0074
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
31/20ScoresViewViewViewViewView