Table of Contents

INK128 0.2μM R02 exp70

Mechanism of Action

Inhibits mTORC1 and mTORC2, ATP-competitive

Technical Notes

Protein References

  • PubChem Name: Sapanisertib
  • Synonyms: INK-128; MLN0128; TAK-228
  • CAS #: 1224844-38-5
  • PubChem CID: 45375953
  • IUPAC: 5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine
  • INCHI Name: InChI=1S/C15H15N7O/c1-7(2)22-14-11(13(16)18-6-19-14)12(21-22)8-3-4-10-9(5-8)20-15(17)23-10/h3-7H,1-2H3,(H2,17,20)(H2,16,18,19)
  • INCHI Key: GYLDXIAOMVERTK-UHFFFAOYSA-N
  • Molecular Weight: 309.33
  • Canonical SMILES: CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)OC(=N4)N)N
  • Isomeric SMILES: N/A
  • Molecular Formula: C15H15N7O

Protein Supplier

  • Supplier Name: Selleck Chemicals
  • Catalog #: S2811
  • Lot #: N/A

Protein Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C15H15N7O 310.14108; found 310.1415

Dose Response Curve

  • Platform ID: INK128
  • Min: -13.2131; Max: 80.1073





IC Concentration (µM)
IC10 N/A
IC20 0.0967
IC30 0.1748
IC40 0.2838
IC50 0.4429
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
0/5ScoresViewViewViewViewView