EFTUD1

Entrez Summary: N/A
UniProt Summary: Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits. {ECO:0000269|PubMed:21536732}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nicotinate 1000μM R03 exp140	-1.73
Rapamycin 1μM R00 exp29	-1.72
Rotenone 20μM R00 exp34	1.73
Pimelic-diphenylamide-106 5μM R00 exp28	1.75
Phenformin 20μM R05 exp212	1.82
AICAR 240μM R03 exp116	1.83
THZ531 0.225μM R08 exp444	1.84
Citral 50μM R06 exp274	1.89
Nicotine 3000μM R08 exp510	2.1
ML-792 0.2μM R08 exp505	2.24

Global Fraction of Cell Lines Where Essential: 284/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	14/28
blood	7/28
bone	8/26
breast	13/33
central nervous system	23/56
cervix	1/4
colorectal	10/17
esophagus	2/13
fibroblast	0/1
gastric	5/16
kidney	10/21
liver	11/20
lung	31/75
lymphocyte	5/16
ovary	15/26
pancreas	13/24
peripheral nervous system	8/16
plasma cell	5/15
prostate	0/1
skin	9/24
soft tissue	5/9
thyroid	0/2
upper aerodigestive	10/22
urinary tract	13/29
uterus	3/5

Expression Distribution

EFG C
GTP EFTU

mature ribosome assembly
translation elongation factor activity
GTP metabolic process
guanosine-containing compound metabolic process
ribosome binding
purine ribonucleoside triphosphate metabolic process
purine ribonucleoside metabolic process
purine nucleoside metabolic process
ribosome assembly
ribonucleoside triphosphate metabolic process
purine nucleoside triphosphate metabolic process
ribonucleoside metabolic process
nucleoside triphosphate metabolic process
nucleoside metabolic process
translational elongation
glycosyl compound metabolic process
ribonucleoprotein complex
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
ribosome biogenesis
purine ribonucleotide metabolic process
ribonucleotide metabolic process
GTPase activity
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
translation
GTP binding
peptide biosynthetic process
nucleotide metabolic process
nucleoside phosphate metabolic process
ribonucleoprotein complex biogenesis
amide biosynthetic process
peptide metabolic process
nucleobase-containing small molecule metabolic process
organelle assembly
cellular amide metabolic process
cellular protein-containing complex assembly
organophosphate metabolic process
carbohydrate derivative metabolic process