PTPN6
Gene Information
- Official Symbol: PTPN6
- Official Name: protein tyrosine phosphatase non-receptor type 6
- Aliases and Previous Symbols: N/A
- Entrez ID: 5777
- UniProt: P29350
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. {ECO:0000269|PubMed:11266449}.
Pfam Domains GO Terms
Pfam Domains
| Y phosphatase |
| SH2 |
GO Terms
| abortive mitotic cell cycle |
| phosphorylation-dependent protein binding |
| alpha-beta T cell receptor complex |
| negative regulation of humoral immune response mediated by circulating immunoglobulin |
| negative regulation of immunoglobulin mediated immune response |
| negative regulation of B cell mediated immunity |
| regulation of humoral immune response mediated by circulating immunoglobulin |
| negative regulation of humoral immune response |
| transmembrane receptor protein tyrosine phosphatase activity |
| megakaryocyte development |
| platelet formation |
| negative regulation of T cell receptor signaling pathway |
| positive regulation of cell adhesion mediated by integrin |
| platelet morphogenesis |
| megakaryocyte differentiation |
| bone cell development |
| natural killer cell mediated cytotoxicity |
| negative regulation of antigen receptor-mediated signaling pathway |
| regulation of B cell differentiation |
| natural killer cell mediated immunity |
| regulation of type I interferon-mediated signaling pathway |
| SH2 domain binding |
| negative regulation of lymphocyte mediated immunity |
| regulation of T cell receptor signaling pathway |
| negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| phosphotyrosine residue binding |
| leukocyte mediated cytotoxicity |
| negative regulation of interleukin-6 production |
| platelet aggregation |
| negative regulation of adaptive immune response |
| regulation of cell adhesion mediated by integrin |
| negative regulation of leukocyte mediated immunity |
| regulation of immunoglobulin mediated immune response |
| negative regulation of peptidyl-tyrosine phosphorylation |
| regulation of B cell mediated immunity |
| T cell costimulation |
| lymphocyte costimulation |
| tertiary granule lumen |
| cell adhesion molecule binding |
| negative regulation of tumor necrosis factor production |
| myeloid cell development |
| homotypic cell-cell adhesion |
| negative regulation of T cell proliferation |
| negative regulation of tumor necrosis factor superfamily cytokine production |
| specific granule lumen |
| regulation of antigen receptor-mediated signaling pathway |
| negative regulation of lymphocyte proliferation |
| negative regulation of MAP kinase activity |
| negative regulation of mononuclear cell proliferation |
| regulation of release of sequestered calcium ion into cytosol |
| negative regulation of leukocyte proliferation |
| positive regulation of phosphatidylinositol 3-kinase signaling |
| hematopoietic progenitor cell differentiation |
| cell killing |
| regulation of calcium ion transport into cytosol |
| protein tyrosine phosphatase activity |
| peptidyl-tyrosine dephosphorylation |
| negative regulation of T cell activation |
| regulation of phosphatidylinositol 3-kinase signaling |
| negative regulation of immune effector process |
| negative regulation of leukocyte cell-cell adhesion |
| regulation of sequestering of calcium ion |
| B cell receptor signaling pathway |
| SH3 domain binding |
| negative regulation of protein serine/threonine kinase activity |
| regulation of humoral immune response |
| platelet activation |
| regulation of interleukin-6 production |
| peptidyl-tyrosine phosphorylation |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| negative regulation of lymphocyte activation |
| peptidyl-tyrosine modification |
| regulation of calcium ion transmembrane transport |
| negative regulation of immune response |
| regulation of tumor necrosis factor production |
| regulation of G1/S transition of mitotic cell cycle |
| regulation of lymphocyte mediated immunity |
| regulation of tumor necrosis factor superfamily cytokine production |
| regulation of T cell proliferation |
| regulation of adaptive immune response |
| regulation of cytokine-mediated signaling pathway |
| regulation of cell cycle G1/S phase transition |
| negative regulation of MAPK cascade |
| regulation of lymphocyte differentiation |
| cell-cell junction |
| negative regulation of cell-cell adhesion |
| negative regulation of leukocyte activation |
| regulation of response to cytokine stimulus |
| negative regulation of cell activation |
| bone development |
| positive regulation of T cell activation |
| regulation of leukocyte mediated immunity |
| regulation of B cell activation |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| protein dephosphorylation |
| positive regulation of leukocyte cell-cell adhesion |
| myeloid cell differentiation |
| regulation of leukocyte proliferation |
| negative regulation of protein kinase activity |
| negative regulation of kinase activity |
| regulation of calcium ion transport |
| regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of cell-cell adhesion |
| lymphocyte mediated immunity |
| negative regulation of cell adhesion |
| regulation of leukocyte differentiation |
| negative regulation of cytokine production |
| negative regulation of transferase activity |
| regulation of ERK1 and ERK2 cascade |
| blood coagulation |
| antigen receptor-mediated signaling pathway |
| coagulation |
| regulation of leukocyte cell-cell adhesion |
| hemostasis |
| dephosphorylation |
| regulation of T cell activation |
| regulation of cation transmembrane transport |
| regulation of MAP kinase activity |
| positive regulation of lymphocyte activation |
| leukocyte migration |
| regulation of metal ion transport |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| negative regulation of protein phosphorylation |
| regulation of mitotic cell cycle phase transition |
| positive regulation of cell activation |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| regulation of cell cycle phase transition |
| immune response-activating cell surface receptor signaling pathway |
| regulation of hemopoiesis |
| regulation of innate immune response |
| protein kinase binding |
| regulation of immune effector process |
| regulation of ion transmembrane transport |
| wound healing |
| immune response-regulating cell surface receptor signaling pathway |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| skeletal system development |
| regulation of body fluid levels |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| cell-cell adhesion |
| negative regulation of intracellular signal transduction |
| leukocyte degranulation |
| regulation of lymphocyte activation |
| regulation of protein serine/threonine kinase activity |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| regulation of response to biotic stimulus |
| cell population proliferation |
| cell morphogenesis involved in differentiation |
| hemopoiesis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| immune response-activating signal transduction |
| regulation of transmembrane transport |
| response to wounding |
| myeloid leukocyte activation |
| negative regulation of protein modification process |
| protein-containing complex |
| immune response-regulating signaling pathway |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of mitotic cell cycle |
| activation of immune response |
| regulation of cell activation |
| immune system development |
| cytokine-mediated signaling pathway |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| mitotic cell cycle |
| regulation of cytokine production |
| regulation of ion transport |
| regulated exocytosis |
| cell morphogenesis |
| regulation of MAPK cascade |
| regulation of cell cycle process |
| regulation of defense response |
| leukocyte mediated immunity |
| innate immune response |
| regulation of multi-organism process |
| negative regulation of catalytic activity |
| exocytosis |
| regulation of protein kinase activity |
| cellular component morphogenesis |
| nucleolus |
| positive regulation of immune response |
| regulation of kinase activity |
| peptidyl-amino acid modification |
| anatomical structure formation involved in morphogenesis |
| positive regulation of cell population proliferation |
| regulation of cellular localization |
| apoptotic process |
| leukocyte activation |
| cell adhesion |
| biological adhesion |
| defense response to other organism |
| cell migration |
| protein phosphorylation |
| regulation of transferase activity |
| secretion by cell |
| cellular response to cytokine stimulus |
| positive regulation of intracellular signal transduction |
| negative regulation of cellular protein metabolic process |
| export from cell |
| programmed cell death |
| cell activation |
| cell motility |
| localization of cell |
| immune effector process |
| cell death |
| regulation of response to external stimulus |
| response to cytokine |
| negative regulation of protein metabolic process |
| secretion |
| negative regulation of molecular function |
| positive regulation of immune system process |
| regulation of immune response |
| regulation of cell cycle |
| negative regulation of multicellular organismal process |
| negative regulation of signal transduction |
| phosphorylation |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| defense response |
| cell cycle |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of protein phosphorylation |
| regulation of response to stress |
| movement of cell or subcellular component |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| cell development |
| regulation of immune system process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| extracellular region |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10517
- Expression level (log2 read counts): 7.48
Expression Distribution
PTPN6 Expression in NALM6 Cells: 7.48
