RIC8A
Gene Information
- Official Symbol: RIC8A
- Official Name: RIC8 guanine nucleotide exchange factor A
- Aliases and Previous Symbols: N/A
- Entrez ID: 60626
- UniProt: Q9NPQ8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Ric8 |
GO Terms
| cell-cell adhesion involved in gastrulation |
| cell migration involved in gastrulation |
| basement membrane organization |
| G-protein alpha-subunit binding |
| visual learning |
| visual behavior |
| associative learning |
| adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| guanyl-nucleotide exchange factor activity |
| learning |
| gastrulation |
| ameboidal-type cell migration |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| cell-cell adhesion via plasma-membrane adhesion molecules |
| learning or memory |
| GTPase activator activity |
| cognition |
| response to light stimulus |
| extracellular matrix organization |
| in utero embryonic development |
| extracellular structure organization |
| positive regulation of GTPase activity |
| response to radiation |
| regulation of GTPase activity |
| cell-cell adhesion |
| vasculature development |
| cardiovascular system development |
| embryonic morphogenesis |
| behavior |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| positive regulation of hydrolase activity |
| circulatory system development |
| cell adhesion |
| biological adhesion |
| cell migration |
| embryo development |
| cell motility |
| localization of cell |
| response to abiotic stimulus |
| regulation of hydrolase activity |
| locomotion |
| G protein-coupled receptor signaling pathway |
| nervous system process |
| positive regulation of catalytic activity |
| movement of cell or subcellular component |
| positive regulation of molecular function |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18971
- Expression level (log2 read counts): 6.57
Expression Distribution
RIC8A Expression in NALM6 Cells: 6.57
