UQCRC1

Entrez Summary: N/A
UniProt Summary: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ONC212 0.15μM R08 exp513	1.79
AICAR 240μM R05 exp211	1.82
Pimelic-diphenylamide-106 5μM R00 exp28	1.83
Oligomycin-A 2μM R00 exp25	1.9
iCRT14 30μM R08 exp492	2.43
Hydroxyurea 100μM R07 exp329	2.83
Ammonium tetrathiomolybdate 10μM R08 exp448	3.14

Global Fraction of Cell Lines Where Essential: 32/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	1/26
breast	2/33
central nervous system	0/56
cervix	1/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	1/21
liver	0/20
lung	5/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	1/15
prostate	0/1
skin	3/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	1/29
uterus	0/5

Expression Distribution

Peptidase M16
Peptidase M16 C

ubiquinol-cytochrome-c reductase activity
mitochondrial respiratory chain complex III
mitochondrial electron transport, ubiquinol to cytochrome c
mitochondrial respirasome
response to activity
aerobic respiration
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
respiratory electron transport chain
response to alkaloid
oxidative phosphorylation
cellular respiration
electron transport chain
ATP metabolic process
energy derivation by oxidation of organic compounds
protein-containing complex binding
ubiquitin protein ligase binding
mitochondrial inner membrane
generation of precursor metabolites and energy
oxidation-reduction process
response to organonitrogen compound
response to nitrogen compound
mitochondrion
phosphorylation