OICR-9429 10μM R03 exp142
Mechanism of Action
Inhibits interaction between WDR5 and MLL1 (KMT2A) in MLL H3K4 trimethylase complex
- Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor
Technical Notes
Compound References
- PubChem Name: N-[2-(4-Methylpiperazin-1-yl)-5-[3-(morpholin-4-ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1H-pyridine-3-carboxamide
- Synonyms: N/A
- CAS #: 1801787-56-3
- PubChem CID: 91623360
- IUPAC: N-[2-(4-methylpiperazin-1-yl)-5-[3-(morpholin-4-ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1H-pyridine-3-carboxamide
- INCHI Name: InChI=1S/C29H32F3N5O3/c1-35-7-9-37(10-8-35)26-6-5-22(21-4-2-3-20(15-21)19-36-11-13-40-14-12-36)16-25(26)34-28(39)23-18-33-27(38)17-24(23)29(30,31)32/h2-6,15-18H,7-14,19H2,1H3,(H,33,38)(H,34,39)
- INCHI Key: DJOVLOYCGXNVPI-UHFFFAOYSA-N
- Molecular Weight: 555.6
- Canonical SMILES: CN1CCN(CC1)C2=C(C=C(C=C2)C3=CC=CC(=C3)CN4CCOCC4)NC(=O)C5=CNC(=O)C=C5C(F)(F)F
- Isomeric SMILES: N/A
- Molecular Formula: C29H32F3N5O3
Compound Supplier
- Supplier Name: Structural Genomics Consortium
- Catalog #: N/A
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C29H32F3N5O3 556.253; found 556.25499
Dose Response Curve
- Platform ID: OICR9429
- Min: -4.8409; Max: 11.8137
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 03
- Dose: 10µM
- Days of incubation: 8
- Doublings: 7.6
- Numbers of reads: 10688227
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 1/0 | Scores |
OICR-9429 10μM R03 exp142
Metformin 40μM R03 exp132 vs OICR-9429 10μM R03 exp142
