Tenofovir 10μM R07 exp405

Mechanism of Action

Nucleoside reverse transcriptase inhibitor, chain terminator

  • Class / Subclass 1: Infectious Disease / Antiviral

Technical Notes

Compound References

  • PubChem Name: Tenofovir
  • Synonyms: GS 1278; PMPA; TDF
  • CAS #: 147127-20-6
  • PubChem CID: 464205
  • IUPAC: [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid
  • INCHI Name: InChI=1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1
  • INCHI Key: SGOIRFVFHAKUTI-ZCFIWIBFSA-N
  • Molecular Weight: 287.21
  • Canonical SMILES: CC(CN1C=NC2=C(N=CN=C21)N)OCP(=O)(O)O
  • Isomeric SMILES: C[C@H](CN1C=NC2=C(N=CN=C21)N)OCP(=O)(O)O
  • Molecular Formula: C9H14N5O4P

Compound Supplier

  • Supplier Name: Toronto Research Chemicals
  • Catalog #: T018500
  • Lot #: 1-JMO-90-1

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M-H)- Calcd for C9H14N5O4P 286.07106; found 286.07163

Dose Response Curve

  • Platform ID: Tenofovir
  • Min: -6.2246; Max: 26.6056





IC Concentration (µM)
IC10 N/A
IC20 N/A
IC30 N/A
IC40 N/A
IC50 N/A
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

  • Round: 07
  • Dose: 10µM
  • Days of incubation: 8
  • Doublings: 6.9
  • Numbers of reads: 24468403

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
2/1ScoresViewViewViewViewView

  • Last modified: 2026/01/15 21:36
  • by 127.0.0.1