PGLS

Entrez Summary: N/A
UniProt Summary: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hydroxyurea 100μM R07 exp329	1.74
Sulforaphane 9μM R08 exp526 no dilution day6	1.79
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.97
Nutlin-3A 1.6μM R06 exp294	1.97
Pterostilbene 16μM R02 exp78	2.08
Arsenate 40μM R06 exp264	2.16
Deferoxamine 11μM R07 exp350	2.35
Q15 2.7μM R02 exp79	2.46
2-Deoxy-D-glucose 800μM R05 exp214	3.71

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

6-phosphogluconolactonase activity
pentose-phosphate shunt, oxidative branch
pentose-phosphate shunt
NADPH regeneration
glucose 6-phosphate metabolic process
NADP metabolic process
generation of precursor metabolites and energy
carbohydrate metabolic process
organophosphate metabolic process
oxidation-reduction process
carbohydrate derivative metabolic process