AEBP2

Entrez Summary: N/A
UniProt Summary: DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3. {ECO:0000269|PubMed:15225548}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Azithromycin 100μM R08 exp452	-2.27
ZLN024 50μM R08 exp538	-2.06
Selumetinib 20μM R02 exp81	-1.99
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.96
Adefovir 20μM R07 exp332	-1.87
LY2090314 0.003μM R08 exp499	-1.85
Cisplatin 0.35μM R06 exp273	1.74
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	1.75
Nifuroxazide 1μM R01 exp51	1.79
TRAIL 5ng/ml R00 exp35	1.8
CCCP 0.1μM R00 exp10	1.86
5-Azacytidine 2μM R07 exp330	2.69
TRAIL 50ng/ml R00 exp36	3.19

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ESC/E(Z) complex
negative regulation of gene expression, epigenetic
regulation of gene expression, epigenetic
transcription corepressor activity
DNA-binding transcription repressor activity, RNA polymerase II-specific
RNA polymerase II proximal promoter sequence-specific DNA binding
chromatin organization
negative regulation of transcription by RNA polymerase II
chromosome organization
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
negative regulation of gene expression