RPL36

Entrez Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L36E family of ribosomal proteins. It is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
UniProt Summary: Component of the large ribosomal subunit. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000305|PubMed:12962325}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 611/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	25/28
blood	23/28
bone	19/26
breast	27/33
central nervous system	49/56
cervix	4/4
colorectal	13/17
esophagus	8/13
fibroblast	1/1
gastric	14/16
kidney	17/21
liver	18/20
lung	55/75
lymphocyte	12/16
ovary	23/26
pancreas	21/24
peripheral nervous system	14/16
plasma cell	8/15
prostate	0/1
skin	23/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	18/22
urinary tract	24/29
uterus	3/5

Expression Distribution

polysomal ribosome
cytosolic large ribosomal subunit
cytoplasmic translation
SRP-dependent cotranslational protein targeting to membrane
cotranslational protein targeting to membrane
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
viral transcription
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
viral gene expression
protein localization to endoplasmic reticulum
translational initiation
protein targeting to membrane
structural constituent of ribosome
nuclear-transcribed mRNA catabolic process
mRNA catabolic process
RNA catabolic process
establishment of protein localization to membrane
protein targeting
nucleobase-containing compound catabolic process
translation
peptide biosynthetic process
establishment of protein localization to organelle
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
protein localization to membrane
organic cyclic compound catabolic process
amide biosynthetic process
peptide metabolic process
mRNA metabolic process
viral process
protein localization to organelle
symbiotic process
cellular amide metabolic process
interspecies interaction between organisms
nucleolus
cellular macromolecule catabolic process
intracellular protein transport
macromolecule catabolic process