XPNPEP1

Entrez Summary: N/A
UniProt Summary: Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hydroxyurea 100μM R07 exp329	-1.96
LY2090314 0.003μM R08 exp499	-1.9
Mdivi-1 15μM R05 exp217	-1.9
BH1 1μM R04 exp169	-1.87
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-1.76
Resveratrol 16μM R03 exp147	-1.73
Taxol 0.004μM R03 exp103	-1.71
CB-5083 0.4μM R08 exp468	1.76
ETC-159 50μM R08 exp480	1.77
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.87
Azithromycin 100μM R08 exp452	1.91
Cerivastatin 0.15μM R05 exp226	1.92
Ibrutinib 10μM R08 exp442	1.97
AICAR 240μM R03 exp116	2.02
MK2206 4μM R08 exp504	2.09
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	2.22

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Peptidase M24
Creatinase N

bradykinin catabolic process
metalloaminopeptidase activity
aminopeptidase activity
peptide catabolic process
manganese ion binding
drug catabolic process
drug metabolic process
peptide metabolic process
cellular amide metabolic process
protein homodimerization activity
organonitrogen compound catabolic process
proteolysis
organic substance catabolic process
cellular catabolic process