AMBRA1

Entrez Summary: N/A
UniProt Summary: Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
QNZ 0.01μM R08 exp439	-2.44
39°C R06 exp303	-2.2
MLN-4924 0.2μM R00 exp21	-2.03
Olaparib 4μM R08 exp512	-1.93
Etoposide 0.3μM R05 exp199	-1.87
LB-100 2μM R05 exp210	-1.78
Aphidicolin 0.4μM R08 exp440	-1.75
Resveratrol 16μM R03 exp147	-1.73
Rotenone 0.07μM R08 exp431	-1.71
Actinomycin-D 0.01μM R00 exp4	1.7
UM0011500 5μM R05 exp245	1.76
BVD-523 15μM R02 exp67	1.91
CCT251545 20μM R07 exp326	2.24
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	2.46
Milciclib 2μM R08 exp502	2.81
UMK57 1μM R01 exp59	3.39
UM131593 0.2μM R03 exp106	4.42
Palbociclib 1μM R07 exp382	8.38

Global Fraction of Cell Lines Where Essential: 8/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	2/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mitophagy
response to mitochondrial depolarisation
negative regulation of cardiac muscle cell apoptotic process
selective autophagy
negative regulation of striated muscle cell apoptotic process
positive regulation of phosphatidylinositol 3-kinase activity
GTPase binding
positive regulation of lipid kinase activity
regulation of cardiac muscle cell apoptotic process
negative regulation of muscle cell apoptotic process
autophagy of mitochondrion
regulation of striated muscle cell apoptotic process
mitochondrion disassembly
positive regulation of phospholipid metabolic process
regulation of phosphatidylinositol 3-kinase activity
phagocytic vesicle
autophagosome assembly
regulation of lipid kinase activity
organelle disassembly
autophagosome organization
regulation of muscle cell apoptotic process
autophagosome
regulation of phospholipid metabolic process
axoneme
positive regulation of autophagy
vacuole organization
positive regulation of lipid metabolic process
negative regulation of neuron apoptotic process
cellular response to starvation
neural tube development
macroautophagy
mitochondrial outer membrane
response to starvation
regulation of neuron apoptotic process
negative regulation of neuron death
cellular response to nutrient levels
autophagy
process utilizing autophagic mechanism
cellular response to extracellular stimulus
ubiquitin protein ligase binding