ARF1
Gene Information
- Official Symbol: ARF1
- Official Name: ADP ribosylation factor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 375
- UniProt: P84077
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).
Pfam Domains GO Terms
Pfam Domains
| G-alpha |
| Gtr1 RagA |
| Ras |
| SRPRB |
| Miro |
| Arf |
GO Terms
| phospholipase D activator activity |
| Golgi to transport vesicle transport |
| mitotic cleavage furrow ingression |
| positive regulation of late endosome to lysosome transport |
| positive regulation of vacuolar transport |
| cleavage furrow ingression |
| lysosomal membrane organization |
| positive regulation of ER to Golgi vesicle-mediated transport |
| regulation of late endosome to lysosome transport |
| regulation of vacuolar transport |
| COPI-coated vesicle |
| synaptic vesicle budding |
| very-low-density lipoprotein particle assembly |
| postsynaptic actin cytoskeleton organization |
| cellular copper ion homeostasis |
| postsynaptic cytoskeleton organization |
| regulation of Arp2/3 complex-mediated actin nucleation |
| regulation of ER to Golgi vesicle-mediated transport |
| copper ion homeostasis |
| long-term synaptic depression |
| positive regulation of calcium ion-dependent exocytosis |
| positive regulation of sodium ion transmembrane transport |
| mitotic cytokinetic process |
| plasma lipoprotein particle assembly |
| regulation of actin nucleation |
| regulation of defense response to virus by virus |
| protein-lipid complex assembly |
| dendritic spine organization |
| cellular response to virus |
| positive regulation of sodium ion transport |
| synaptic vesicle transport |
| cytokinetic process |
| neuron projection organization |
| synaptic vesicle localization |
| cell leading edge |
| positive regulation of dendritic spine development |
| regulation of calcium ion-dependent exocytosis |
| plasma lipoprotein particle organization |
| interleukin-12-mediated signaling pathway |
| cellular response to interleukin-12 |
| protein-lipid complex subunit organization |
| response to interleukin-12 |
| sarcomere |
| positive regulation of regulated secretory pathway |
| regulation of receptor internalization |
| peroxisomal membrane |
| lytic vacuole organization |
| lysosome organization |
| Golgi to plasma membrane transport |
| negative regulation of synaptic transmission |
| regulation of sodium ion transmembrane transport |
| mitotic cytokinesis |
| regulation of plasma lipoprotein particle levels |
| positive regulation of dendrite development |
| regulation of dendritic spine development |
| GDP binding |
| regulation of phospholipid metabolic process |
| regulation of sodium ion transport |
| postsynapse organization |
| positive regulation of exocytosis |
| vesicle-mediated transport to the plasma membrane |
| cytoskeleton-dependent cytokinesis |
| vesicle budding from membrane |
| cytokinesis |
| antigen processing and presentation of exogenous peptide antigen via MHC class II |
| antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| positive regulation of endocytosis |
| antigen processing and presentation of peptide antigen via MHC class II |
| regulation of receptor-mediated endocytosis |
| post-Golgi vesicle-mediated transport |
| cellular transition metal ion homeostasis |
| phosphatidylinositol biosynthetic process |
| late endosome |
| vacuole organization |
| transition metal ion homeostasis |
| plasma membrane invagination |
| positive regulation of cation transmembrane transport |
| membrane invagination |
| regulation of dendrite development |
| positive regulation of ion transmembrane transport |
| regulation of regulated secretory pathway |
| regulation of actin filament polymerization |
| phosphatidylinositol metabolic process |
| trans-Golgi network |
| establishment of vesicle localization |
| antigen processing and presentation of exogenous peptide antigen |
| regulation of actin polymerization or depolymerization |
| antigen processing and presentation of exogenous antigen |
| regulation of actin filament length |
| vesicle localization |
| regulation of synaptic plasticity |
| antigen processing and presentation of peptide antigen |
| postsynaptic membrane |
| positive regulation of transmembrane transport |
| regulation of endocytosis |
| glycerophospholipid biosynthetic process |
| positive regulation of intracellular transport |
| magnesium ion binding |
| antigen processing and presentation |
| glycerolipid biosynthetic process |
| regulation of protein polymerization |
| regulation of exocytosis |
| actin filament organization |
| protein domain specific binding |
| phospholipid biosynthetic process |
| postsynaptic density |
| regulation of actin filament organization |
| synapse organization |
| positive regulation of protein secretion |
| positive regulation of ion transport |
| positive regulation of neuron projection development |
| response to virus |
| positive regulation of peptide secretion |
| vesicle organization |
| glycerophospholipid metabolic process |
| neuron projection |
| GTPase activity |
| regulation of cation transmembrane transport |
| regulation of actin cytoskeleton organization |
| glutamatergic synapse |
| regulation of supramolecular fiber organization |
| regulation of intracellular transport |
| establishment of organelle localization |
| positive regulation of neuron differentiation |
| Golgi vesicle transport |
| phospholipid metabolic process |
| regulation of cellular component size |
| glycerolipid metabolic process |
| positive regulation of cell projection organization |
| regulation of metal ion transport |
| extracellular structure organization |
| regulation of actin filament-based process |
| GTP binding |
| regulation of lipid metabolic process |
| positive regulation of secretion by cell |
| focal adhesion |
| positive regulation of protein transport |
| positive regulation of secretion |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| positive regulation of neurogenesis |
| regulation of ion transmembrane transport |
| protein heterodimerization activity |
| cell division |
| actin cytoskeleton organization |
| regulation of peptide secretion |
| regulation of neuron projection development |
| regulation of anatomical structure size |
| positive regulation of nervous system development |
| organophosphate biosynthetic process |
| regulation of cytoskeleton organization |
| positive regulation of cell development |
| regulation of vesicle-mediated transport |
| cellular metal ion homeostasis |
| regulation of transmembrane transport |
| actin filament-based process |
| lipid biosynthetic process |
| organelle localization |
| protein-containing complex |
| mitotic cell cycle process |
| Golgi membrane |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| regulation of neuron differentiation |
| cytokine-mediated signaling pathway |
| mitotic cell cycle |
| regulation of plasma membrane bounded cell projection organization |
| perinuclear region of cytoplasm |
| regulation of ion transport |
| viral process |
| cation homeostasis |
| regulation of protein transport |
| regulation of cell projection organization |
| inorganic ion homeostasis |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| symbiotic process |
| ion homeostasis |
| regulation of secretion |
| regulation of neurogenesis |
| interspecies interaction between organisms |
| membrane organization |
| organophosphate metabolic process |
| cellular homeostasis |
| regulation of cellular localization |
| regulation of nervous system development |
| regulation of cell development |
| cellular lipid metabolic process |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| Golgi apparatus |
| positive regulation of transport |
| intracellular protein transport |
| cell cycle process |
| cellular response to cytokine stimulus |
| regulation of protein localization |
| response to cytokine |
| cytoskeleton organization |
| chemical homeostasis |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| positive regulation of cellular component organization |
| lipid metabolic process |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| cell cycle |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| RNA binding |
| positive regulation of catalytic activity |
| protein transport |
| intracellular transport |
| generation of neurons |
| peptide transport |
| protein-containing complex assembly |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| neurogenesis |
| homeostatic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| regulation of transport |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 32/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 3/28 |
| blood | 1/28 |
| bone | 1/26 |
| breast | 1/33 |
| central nervous system | 2/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 1/13 |
| fibroblast | 0/1 |
| gastric | 2/16 |
| kidney | 0/21 |
| liver | 1/20 |
| lung | 1/75 |
| lymphocyte | 0/16 |
| ovary | 1/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 3/22 |
| urinary tract | 2/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16308
- Expression level (log2 read counts): 7.68
Expression Distribution
ARF1 Expression in NALM6 Cells: 7.68
