CACNA1S

Entrez Summary: This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility. [provided by RefSeq, Jul 2008].
UniProt Summary: Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. {ECO:0000250|UniProtKB:P07293}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Oligomycin-A 20μM R00 exp26	-1.95
iCRT14 30μM R08 exp492	-1.74
VER-155008 3.9μM R06 exp301	-1.73
5-Fluorouracil 2μM R00 exp1	1.72
UNC2400 2μM R03 exp156	1.75
Geldanamycin 0.01μM R05 exp235	1.8
Betulinic acid 10 to 15μM on day4 R05 exp222	1.98
Thioridazine 5μM R08 exp530	2.01
Parthenolide 2.5μM R05 exp238	2.11
UM0130462 0.025 to 0.035μM day4 R05 exp247	2.37

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

high voltage-gated calcium channel activity
cellular response to caffeine
L-type voltage-gated calcium channel complex
cellular response to purine-containing compound
response to caffeine
response to diuretic
I band
voltage-gated calcium channel complex
cellular response to alkaloid
voltage-gated calcium channel activity
T-tubule
calcium ion import
cardiac conduction
response to alkaloid
multicellular organismal signaling
response to purine-containing compound
cellular response to xenobiotic stimulus
calcium ion transmembrane transport
calmodulin binding
regulation of heart contraction
calcium ion transport
muscle contraction
regulation of blood circulation
divalent metal ion transport
muscle system process
response to xenobiotic stimulus
divalent inorganic cation transport
cellular response to drug
regulation of ion transmembrane transport
cellular response to organic cyclic compound
inorganic cation transmembrane transport
regulation of transmembrane transport
regulation of system process
cellular response to organonitrogen compound
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
cellular response to nitrogen compound
regulation of ion transport
cation transport