CD47

Gene Information

Official Symbol: CD47
Official Name: CD47 molecule
Aliases and Previous Symbols: N/A
Entrez ID: 961
UniProt: Q08722
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection. {ECO:0000250, ECO:0000269|PubMed:11509594, ECO:0000269|PubMed:15383453, ECO:0000269|PubMed:7691831}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LY2090314 0.003μM R08 exp499	-2.2
LY2090314 0.003μM R08 exp500 no dilution day6	-1.79
2-Deoxy-D-glucose 800μM R05 exp214	-1.78
2-Methoxyestradiol 0.2μM R01 exp40	1.72
QNZ 0.01μM R08 exp439	1.76
DKK1 89ng/ml R08 exp477	1.8
Menadione 5μM R06 exp292	1.96
GSK343 3μM R03 exp124	1.97
ZLN024 50μM R08 exp538	2.16

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7504
Expression level (log2 read counts): 8.17

Expression Distribution

negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
thrombospondin receptor activity
monocyte extravasation
regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
protein binding involved in heterotypic cell-cell adhesion
opsonization
regulation of Fc receptor mediated stimulatory signaling pathway
negative regulation of phagocytosis
cell-cell adhesion mediator activity
heterotypic cell-cell adhesion
cellular extravasation
cellular response to interleukin-12
mononuclear cell migration
response to interleukin-12
positive regulation of stress fiber assembly
regulation of interleukin-10 production
regulation of interleukin-12 production
regulation of nitric oxide biosynthetic process
positive regulation of actin filament bundle assembly
positive regulation of phagocytosis
tertiary granule membrane
regulation of stress fiber assembly
regulation of reactive oxygen species biosynthetic process
regulation of actomyosin structure organization
specific granule membrane
regulation of actin filament bundle assembly
integrin-mediated signaling pathway
regulation of phagocytosis
regulation of interferon-gamma production
negative regulation of immune effector process
myeloid leukocyte migration
positive regulation of inflammatory response
regulation of interleukin-6 production
regulation of tumor necrosis factor production
regulation of tumor necrosis factor superfamily cytokine production
cellular response to interferon-gamma
cellular response to interleukin-1
regulation of reactive oxygen species metabolic process
response to interferon-gamma
positive regulation of supramolecular fiber organization